All around the world there are major casinos just waiting to be explored, here are our picks of the best gambling cities in the USA and around the World for you to. This is a list of casinos in the United States. Contents. [hide]. 1 Lists by locale. Territory; Otero · New Mexico, Native American. Cities of Gold Casino · Pojoaque Pueblo · Santa Fe · New Mexico, Native American, north of Santa Fe. The following are the top 10 casino cities in the US. A few of them are already a famous city in America, meaning that they offer other attractions besides gaming. New Orleans became the center of American gambling in the early 19th century. Also some casinos in adjacent states are only a short drive away. Even though a major part of the economy is taking a downturn in Detroit, it looks like the gaming market is still thriving. Fair Grounds Race Course. Philadelphia is a historic town that many love to come and visit. Atlantic City has a timeless feel to it. Philadelphia is also home to some of the greatest horse races as well. Do You Know The Real Names Of These DC Heroes? Ohio's first casino opened on May 14, in the historic former Higbee's Building in Tower City Center on Public Square. They soon headed back to the casinos to find comfort and entertainment. The ultimate source for US players. Part of the Pearl River Resort. Cache Creek Casino Resort. Confederated Tribes of Coos, Lower Umpqua and Siuslaw Indians. Gary, Indiana, on the southern tip of Lake Michigan, is on the eastern edge of the Chicago metropolitan area and is also known as Chicagoland. The oldest casino in the city, the Greektown, is Native American-owned and dedicated to helping the economy. Penn National Race Course. The Orleans Hotel and Casino.